普洛药业
DS Technology Platforms
Flow Chemistry Synthetic Biology & Biocatalysis Highly Potent Compound Peptide TPD/PROTAC Oligonucleotide Synthesis Crystallization & Particle Engineering Preparation & Separation
Flow Chemistry Platform
Apeloa has established an industry-leading flow chemistry platform with over a decade of flow chemistry experience, a multi-site network of manufacturing, development, and analytical facilities, combined with world-class scientists. Our state-of-the-art facilities offer quick and economical viable solutions to tackle process challenges under conventional batch mode, with services from feasibility, process development and optimization (PD&O), scale-up to commercial production.
普洛药业
Team
Our flow chemistry services are supported by highly educated and experienced teams across our global network facilities. Our Boston (USA) site offers leading expertise in early-stage flow chemistry, while our Shanghai and Hengdian (China) sites can efficiently develop gram to kilogram scale samples, supported by advanced analytical technology and skilled scientists.
Service
普洛药业
Apeloa offers comprehensive flow chemistry expertise covering the entire lifecycle, from early development to manufacturing of intermediates and active pharmaceutical ingredients (APIs).
Feasibility study (FTE/FFS for early stage development)
Process development & optimization (PD&O)
Scale-up and Proof of concept study
Commercial equipment design
Variable scale sample preparation
Non-GMP and cGMP commercial manufacturing
The advantages of fluid chemistry: green, safe, economical, fast, and flexible
Flow Chemistry Reactions
普洛药业
Flow chemistry can be an ideal approach for synthesis routes involving high-risk conditions, such as highly exothermic, explosive, light-activated, or highly complex multi-step synthesis routes. Apeloa has demonstrated scientific excellence with a wide range of flow chemistry reactions.
Range of Flow Chemistry Reactors
Apeloa has built a full complement of flow chemistry reactors for different scale and stage of development, including lab-scale reactors (g to 1kg scale) and Non-GMP & cGMP commercial production scale reactors (up to tons/year).
Laboratory scale fluid reactor :
Microreactors (stainless steel, silicon carbide, Hastelloy&glass)
Tubular reactors (stainless steel and Hastelloy)
Tangential reactor (stainless steel and Hastelloy)
Photoreactor (light) with adjustable UVLED radiation and glass tube
Circulating reactor
Non GMP/GMP commercial scale fluid reactors :
Microreactor
Tubular reactor (Monel alloy)
Tubular reactor (stainless steel 316L)
  • MICRO REACTOR
    MICRO REACTOR
  • TUBULAR REACTOR
    TUBULAR REACTOR
  • CSTR
    CSTR
  • TANGENTIAL REACTOR(HC)
    TANGENTIAL REACTOR(HC)
  • PHOTO REACTOR
    PHOTO REACTOR
  • MICRO REACTOR-Glass
    MICRO REACTOR-Glass
普洛药业
MICRO REACTOR
普洛药业
TUBULAR REACTOR
普洛药业
CSTR
普洛药业
TANGENTIAL REACTOR(HC)
普洛药业
PHOTO REACTOR
普洛药业
MICRO REACTOR-Glass